The long running cartoon series features an anti-MMA episode:

When the male population of Springfield becomes obsessed with Mixed Martial Arts, Marge and some friends organize a protest. A MMA show promoter gets wind of Marge's protest and challenges her to a match and agrees to shut down the show if Marge wins.

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http://sports.yahoo.com/mma/blog/cagewriter/post/MMA-under-attack-from-The-Simpsons-on-Sunday?urn=mma,194886